Wisepowder ili ndi mitundu yonse yazida zopangira Ukalamba ndi Kukalamba, ndipo ili ndi njira zowongolera zabwino zonse.

Kuwonetsa 1-4 ya zotsatira za 13

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Ukalamba & Ukalamba (Anti-ukalamba)

Kukalamba ndichinthu chomwe tonsefe timachita koma timamvetsetsa zochepa chabe. Ubongo wanu umasintha mukamakalamba zomwe zimatha kukhala ndi zovuta zazing'ono kukumbukira kwanu kapena luso lanu loganiza Ndizosavuta kupanga mndandanda wazosintha zonse zomwe zimadza ndi msinkhu - kukumbukira kukumbukira, makwinya, kutayika kwa minofu.
Katemera (anti-okalamba) imatha kukhala nkhani yovuta kuthana nayo: nkhondo idamenyedwera pano chifukwa cha tanthauzo la mawu mufukufuku ndi zamankhwala, komanso ngati chida chazogulitsa mwamphamvu komanso nthawi zambiri zachinyengo.
Katemera (Anti-okalamba) tsopano ali ndi matanthauzidwe osiyana siyana ndi tanthauzo.
-Magulu asayansi odana ndi ukalamba (kafukufuku wokhudza kukalamba) amatanthauza kuchepa, kupewa, kapena kusintha kukalamba. Ngakhale tsogolo likuwoneka labwino kwambiri, pakadali pano palibe ukadaulo wazachipatala womwe umatsimikizira kapena kubweza ukalamba mwa anthu.
-M'mabizinesi azachipatala komanso odziwika bwino, mankhwala odana ndi ukalamba amatanthauza kuzindikira koyambirira, kupewa, ndi kuchiza matenda okalamba. Izi ndizosiyana kwambiri ndi kuthana ndi ukalamba wokha, ndipo pali njira zingapo komanso zamankhwala zomwe zikupezeka pano. Mwachitsanzo chithandizo cha Alzheimer's, matenda omwe amakhudzana ndi ukalamba.
-M'mabizinesi ambiri - omwe akuphatikizapo zochitika zambiri zachinyengo kapena zopanda pake - anti-ukalamba ndi dzina lofunika komanso njira yowonjezerapo yowonjezera malonda.

Ntchito yoletsa ukalamba

Munjira iyi, zinthu zotsutsana ndi ukalamba zikuchulukirachulukira. Ntchito yothana ndi ufa wothandizira ndi monga:
-Zopangira zosamalira
- Zakudya zopatsa thanzi
-Zakumwa zakumwa
-Pamwamba
Chithandizo cha okalamba & Alzheimer's
Pafupifupi 3% mwa anthu azaka zapakati pa 65 ndi 74, 19% pakati pa 75 ndi 84, ndipo pafupifupi theka la iwo azaka zopitilira 85 ali ndi matenda amisala. Matenda a matenda a Alzheimer's, matenda a cerebrovascular, matenda a Parkinson ndi matenda a Lou Gehrig.
Ukalamba ndiwo chiopsezo chachikulu cha matenda a Alzheimer's. Alzheimer's ndi mtundu wa dementia womwe umayambitsa mavuto ndi kukumbukira, kuganiza ndi machitidwe. Zizindikiro za Alzheimer's nthawi zambiri zimayamba pang'onopang'ono ndikuwonjezeka pakapita nthawi, zimakhala zazikulu mokwanira kusokoneza ntchito za tsiku ndi tsiku. "Tikudziwa kuti ukalamba ndiwo chinthu chachikulu kwambiri chomwe chimayambitsa matenda a Alzheimer's, motero sizosadabwitsa kuti tinapeza mankhwala osokoneza bongo omwe amatinso okalamba,"
FDA idavomerezanso monga Namzaric, kuphatikiza kwa Namenda (memantine) ndi Aricept, pofuna kuchiza matenda othana kwambiri ndi matenda a Alzheimer's.
Namendais (memantine) amakhulupirira kuti amagwira ntchito mwa kukhazikitsa glutamate, mankhwala ofunikira aubongo. Akapangidwa mopitirira muyeso, glutamate imatha kubweretsa kufa kwa ubongo. Chifukwa adani a NMDA amagwira ntchito mosiyana ndi cholineterase inhibitors, mitundu iwiri ya mankhwalawa imatha kutumizidwa palimodzi.
Zinthu zatsopano zambiri zimadziwika kuti ndizothandiza kuchiza matenda a Alzheimer's. Monga ufa wa J-147, ufa wa CMS121.

Mankhwala okalamba okalamba

J-147 ufa (1146963-51-0): J147 ndichinthu chamakono cham'moyo, zawonetsedwa kuti zithandizira matenda a Alzheimer's ndikusintha ukalamba mu mbewa ndipo zatsala pang'ono kukonzekera mayesero azachipatala mwa anthu. Gululi likuchita kale maphunziro owonjezera pama mamolekyulu omwe asinthidwa ndi zomwe J147 adachita mitochondrial ATP synthase-yomwe itha kukhala njira zatsopano zamankhwala. J147 yatsiriza kuyesa koyenera kwa FDA koyenera kwa zinyama.
Alpha-lipoic acid ufa (1077-28-7): Alpha-lipoic acid ndi mankhwala onga vitamini omwe amatchedwa antioxidant, zomwe zikutanthauza kuti amateteza ku ubongo pakakhala kuwonongeka kapena kuvulala.
Alpha-lipoic acid ikuwoneka kuti imathandizira kupewa kuwonongeka kwa maselo ena mthupi, komanso kubwezeretsanso kuchuluka kwa mavitamini monga vitamini E ndi vitamini C. Palinso umboni kuti alpha-lipoic acid imatha kupititsa patsogolo ntchito ndi kuperekera kwa ma neurons mu shuga.
Kuchepetsa kukumbukira ndi nkhawa yomwe imakhala pakati pa okalamba. Amakhulupirira kuti kuwonongeka kwa kupsinjika kwa oxidative kumathandizira kwambiri pakuiwala kukumbukira.
Chifukwa alpha-lipoic acid ndi antioxidant yamphamvu, kafukufuku wapenda kuthekera kwake pakuchepetsa kukula kwa zovuta zomwe zimadziwika ndikutha kukumbukira, monga matenda a Alzheimer's.
Yisiti, chiwindi, impso, sipinachi, broccoli, ndi mbatata ndi zinthu zabwino za alpha-lipoic acid.
CMS121 ufa (1353224-53-9): Ma Geroprotectors ndi zinthu zomwe zimatha kuchepetsa kuchepa kwa chiweto poyang'ana ukalamba. Kafukufuku watsopanoyu amawunika mankhwala angapo ndikuzindikiritsa ena omwe amateteza ma neuron kuti asavulale pochepetsa ukalamba; ofufuzawo adatcha mankhwalawa ma geroneuroprotectors.
Pogwiritsa ntchito mankhwala awa ngati maziko, ofufuzawo adapanga anthu atatu omwe ali ndi vuto la mankhwala a Alzheimer's lotchedwa CMS121, CAD31, ndi J147; amagwiritsanso ntchito fisetin ndi curcumin mwachindunji. Gululi linawonetsa kuti mitundu isanu yonseyi idachepetsa zotsalira za ukalamba, kuwonjezera kuchuluka kwa mbewa ndi ntchentche, ndikuchepetsa zizindikiro za dementia.

Zopezeka ukalamba

Ukalamba ndimomwe nthawi imakhudzira thupi la munthu, ndipo zimachitika pamitundu yambiri:
-Kukalamba. Maselo a zaka malinga ndi kuchuluka kwa nthawi zomwe adabwereza. Selo imatha kubwereza nthawi ngati 50 ma genetic asatulutsidwe molondola, zomwe zimachitika chifukwa cha kufupikitsa ma telomeres. Zowonongeka zochuluka zomwe zimachitika m'maselo mwa ma free radicals ndi zinthu zina, ma cell ambiri amafunikiranso.
-Kukalamba kwachulukidwe. Ma mahormoni amathandizira kwambiri kukalamba, makamaka pakukula kwaubwana ndi uchikulire wa achinyamata. Miyezo ya mahomoni amasintha m'moyo. Kutha msinkhu kumabweretsa ziphuphu ndi ma pores akuluakulu. Tikamakalamba, kusintha kwa ma mahomoni kumabweretsa khungu louma komanso kusintha kwa thupi.
-Zowonongeka. Zowonongeka zowonongeka ndizonse zakunja. Kukhazikika poizoni, dzuwa, zakudya zoyipa, kuipitsa utsi ndi utsi zimasokoneza thupi. Popita nthawi, zinthu zakunja izi zimatha kuwononga minyewa ndipo thupi limatsalira chifukwa chokhoza kusamalira ndi kukonza maselo, minofu, komanso ziwalo.
-Kukalamba kwaMetabolic. Mukamayenda tsiku lanu, maselo anu amasintha chakudya kukhala mphamvu, zomwe zimatulutsa zomwe zimatha kukhala zovulaza. Njira yogwiritsira ntchito metabolism ndikupanga mphamvu imabweretsa kuwonongeka kwa thupi pakapita nthawi. Ena amakhulupirira kuti kuchepa kwa kayendedwe ka metabolic kudzera machitidwe monga kuletsa kachulukidwe kungachedwetse kukalamba mwa anthu.
Zizindikiro zodziwika bwino za Alzheimer's zimaphatikizapo kusowa tulo, kuyendayenda, kusokonezeka, kuda nkhawa, kuchita zachiwawa, kupsinjika, komanso kukhumudwa. Asayansi akuphunzira chifukwa chake zizindikirazi zimachitika ndipo akuphunzira njira zatsopano monga mankhwala osokoneza bongo komanso mankhwalawa.

Tsamba:

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  2. Kuyesera kwamankhwala omwe akuwunika matenda a Alzheimer akuwonetsa zotsatira zakulimbana ndi ukalamba ”(Press release). Salk Institute. 12 Novembala 2015. Yobwezeretsedwa Novembala 13, 2015.
  3. Ochita kafukufuku adazindikira kuchuluka kwa J147, yomwe ikuyandikira mayeso azachipatala kuti athetse matenda a Alzheimer's ". Kubwezeretsedwa 2018-01-30.
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